HCC_015

Measurements require clinical review. Bounding-box diameter is not a validated RECIST measurement.

• CLARIS completed a case investigation for HCC_015 with status completed_with_review_flags.
• AFP is available as an observed source value: 3.6 ng/mL. Structured clinical context is available from the normalized PatientCase with 52 observed clinical records. Liver-function assessment is incomplete because required clinical fields are unavailable: bilirubin, albumin, INR, platelets, complete_liver_function_panel.
• Current mask-derived imaging measurements are available: lesion count 1, largest lesion volume 62.3191 cm3, approximate bounding-box diameter 55.117 mm.
• Treatment context is available from source records. TACE treatment context is observed. Source response observations are available and preserved as source fields; CLARIS has not recalculated formal response criteria. Formal longitudinal treatment response cannot be established by CLARIS because previous/current compatible imaging measurements are unavailable.

• Checkpoint 7 orchestrates available CLARIS capabilities; it does not synthesize a final clinical recommendation.
• Routing is deterministic for auditability and will be compared with LLM-assisted routing later.
• Checkpoint 8 retrieves only from the controlled CLARIS evidence corpus.
• Evidence records are curated source notes with provenance, not full redistributed guideline documents.
• The Evidence Investigation Agent does not generate treatment recommendations.
• Evidence support means relevant controlled-corpus support was found; it is not clinical validation.
• The current HCC-TACE-Seg metadata does not include raw lab reports.
• TotalSegmentator output is treated as candidate imaging evidence, not a clinical diagnosis.

• EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma (European Association for the Study of the Liver, 2018)post_tace_interpretation_requires_follow_up_contexteasl_hcc_guideline_2018_tace
• AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma (American Association for the Study of Liver Diseases, 2023)afp_is_context_not_standalone_responseaasld_hcc_guidance_2023_biomarkers
• AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma (American Association for the Study of Liver Diseases, 2023)liver_function_missing_limits_contextaasld_hcc_guidance_2023_multidisciplinary
• CLARIS curated response-criteria limitation note (CLARIS, 2026)formal_treatment_response_not_calculatedrecist_mrecist_limitation_note
• ACR LI-RADS Treatment Response Assessment (American College of Radiology, 2024)formal_treatment_response_not_calculatedacr_lirads_treatment_response_overview
• CLARIS curated mask-measurement boundary note (CLARIS, 2026)mask_measurements_require_reviewclaris_mask_measurement_boundary_note
• CLARIS curated longitudinal sufficiency note (CLARIS, 2026)previous_measurements_missing_limits_longitudinal_comparisonclaris_missing_previous_measurement_note

• CLARIS completed a case investigation for HCC_015 with status completed_with_review_flags.SUPPORTED
• AFP is available as an observed source value: 3.6 ng/mL.SUPPORTED
• Structured clinical context is available from the normalized PatientCase with 52 observed clinical records.REVIEW
• Current mask-derived imaging measurements are available: lesion count 1, largest lesion volume 62.3191 cm3, approximate bounding-box diameter 55.117 mm.REVIEW
• Treatment context is available from source records. TACE treatment context is observed.SUPPORTED
• Source response observations are available and preserved as source fields; CLARIS has not recalculated formal response criteria.REVIEW
• Formal longitudinal treatment response cannot be established by CLARIS because previous/current compatible imaging measurements are unavailable.INSUFFICIENT
• Source response fields are present, but CLARIS comparison is insufficient; this creates a review-required provenance gap.REVIEW
• Controlled-corpus evidence was retrieved for the case-specific questions with 7 unique sources.REVIEW
• Relevant controlled-corpus evidence was found for post-TACE HCC interpretation context.SUPPORTED
• Controlled-corpus evidence supports the boundary that formal response criteria were not recalculated by CLARIS.SUPPORTED
• Controlled-corpus evidence supports treating AFP as contextual information rather than standalone response assessment.SUPPORTED
• Liver-function assessment is incomplete because required clinical fields are unavailable: bilirubin, albumin, INR, platelets, complete_liver_function_panel.INSUFFICIENT
• AFP trend is unavailable; only single-value AFP context is present.INSUFFICIENT
• Source response fields exist, but CLARIS did not complete its own previous/current quantitative imaging comparison.REVIEW

• reviewSource response fields exist, but CLARIS did not complete its own previous/current quantitative imaging comparison.Review Required · Provenance
• reviewSource response fields are available, but CLARIS has not completed a compatible previous/current imaging comparison.Unresolved · Provenance Gap