CLARIS
Clinical Investigation Workstation
DR
Evidence

HCC_015 evidence and claim trace

Controlled evidence retrieval, claim-level provenance, unsupported-claim checks, limitations, missing fields and contradictions for the active case.

7 sources
Controlled evidence retrieval
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
European Association for the Study of the Liver · 2018
Referenced
What evidence is relevant to interpreting HCC after TACE?
post_tace_interpretation_requires_follow_up_context
easl_hcc_guideline_2018_tace
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
American Association for the Study of Liver Diseases · 2023
Referenced
What evidence is relevant to interpreting HCC after TACE?
afp_is_context_not_standalone_response
aasld_hcc_guidance_2023_biomarkers
AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
American Association for the Study of Liver Diseases · 2023
Referenced
What evidence is relevant to interpreting HCC after TACE?
liver_function_missing_limits_context
aasld_hcc_guidance_2023_multidisciplinary
CLARIS curated response-criteria limitation note
CLARIS · 2026
Retrieved
What evidence is relevant to source response fields and formal response criteria boundaries?
formal_treatment_response_not_calculated
recist_mrecist_limitation_note
ACR LI-RADS Treatment Response Assessment
American College of Radiology · 2024
Retrieved
What evidence is relevant to source response fields and formal response criteria boundaries?
formal_treatment_response_not_calculated
acr_lirads_treatment_response_overview
CLARIS curated mask-measurement boundary note
CLARIS · 2026
Retrieved
What evidence is relevant to interpreting current mask-derived measurements?
mask_measurements_require_review
claris_mask_measurement_boundary_note
CLARIS curated longitudinal sufficiency note
CLARIS · 2026
Retrieved
What evidence is relevant to interpreting current mask-derived measurements?
previous_measurements_missing_limits_longitudinal_comparison
claris_missing_previous_measurement_note
Claim provenance
CLARIS completed a case investigation for HCC_015 with status completed_with_review_flags.
case_investigation_completed · patient_summary
SUPPORTED
Derived values
No derived values.
References
  • case_investigation_result:investigation_status
AFP is available as an observed source value: 3.6 ng/mL.
afp_available · clinical_context
SUPPORTED
Derived values
No derived values.
References
  • case_investigation_result:evidence_collected[name=AFP]
Structured clinical context is available from the normalized PatientCase with 52 observed clinical records.
structured_clinical_context_available · clinical_context
REVIEW
Derived values
No derived values.
References
  • case_investigation_result:clinical_result.available_evidence
Limitations
  • The current HCC-TACE-Seg metadata does not include raw lab reports.
Current mask-derived imaging measurements are available: lesion count 1, largest lesion volume 62.3191 cm3, approximate bounding-box diameter 55.117 mm.
current_imaging_measurements_available · imaging_context
REVIEW
Derived values
No derived values.
References
  • case_investigation_result:evidence_collected[name=current_imaging_measurements]
  • case_investigation_result:imaging_execution_result.current_imaging_result.findings
Limitations
  • TotalSegmentator output is treated as candidate imaging evidence, not a clinical diagnosis.
  • Measurements are computed from segmentation masks and require clinician/radiologist review.
  • Approximate max diameter is bounding-box based in this POC, not a validated RECIST measurement.
Treatment context is available from source records. TACE treatment context is observed.
treatment_context_available · treatment_response_context
SUPPORTED
Derived values
No derived values.
References
  • case_investigation_result:evidence_collected[name=treatment_context]
  • case_investigation_result:treatment_response_context.treatment_summary
Source response observations are available and preserved as source fields; CLARIS has not recalculated formal response criteria.
source_response_fields_preserved_not_recalculated · treatment_response_context
REVIEW
Derived values
No derived values.
References
  • case_investigation_result:evidence_collected[name=source_response_observations]
  • case_investigation_result:treatment_response_context.response_summary
Limitations
  • Source response labels are dataset fields and are not independently recomputed by CLARIS.
Formal longitudinal treatment response cannot be established by CLARIS because previous/current compatible imaging measurements are unavailable.
formal_treatment_response_not_established · treatment_response_context
INSUFFICIENT
Derived values
No derived values.
References
  • case_investigation_result:missing_information[name=previous_current_imaging_comparison]
Source response fields are present, but CLARIS comparison is insufficient; this creates a review-required provenance gap.
source_response_requires_review · treatment_response_context
REVIEW
Derived values
No derived values.
References
  • case_investigation_result:conflicts[name=source_response_without_claris_comparison]
Controlled-corpus evidence was retrieved for the case-specific questions with 7 unique sources.
controlled_evidence_retrieved · evidence_summary
REVIEW
Derived values
No derived values.
References
  • evidence_investigation_result:retrieved_sources
  • easl_hcc_guideline_2018_tace
  • aasld_hcc_guidance_2023_biomarkers
  • aasld_hcc_guidance_2023_multidisciplinary
  • recist_mrecist_limitation_note
  • acr_lirads_treatment_response_overview
  • claris_mask_measurement_boundary_note
  • claris_missing_previous_measurement_note
Limitations
  • Checkpoint 8 retrieves only from the controlled CLARIS evidence corpus.
  • Evidence records are curated source notes with provenance, not full redistributed guideline documents.
  • The Evidence Investigation Agent does not generate treatment recommendations.
Relevant controlled-corpus evidence was found for post-TACE HCC interpretation context.
post_tace_evidence_supported · evidence_summary
SUPPORTED
Derived values
No derived values.
References
  • evidence_investigation_result:supported_points[question_id=post_tace_context]
  • easl_hcc_guideline_2018_tace
  • aasld_hcc_guidance_2023_biomarkers
  • aasld_hcc_guidance_2023_multidisciplinary
Controlled-corpus evidence supports the boundary that formal response criteria were not recalculated by CLARIS.
response_criteria_boundary_supported · evidence_summary
SUPPORTED
Derived values
No derived values.
References
  • evidence_investigation_result:supported_points[question_id=response_criteria_boundary]
  • recist_mrecist_limitation_note
  • acr_lirads_treatment_response_overview
  • easl_hcc_guideline_2018_tace
Controlled-corpus evidence supports treating AFP as contextual information rather than standalone response assessment.
afp_context_evidence_supported · evidence_summary
SUPPORTED
Derived values
No derived values.
References
  • evidence_investigation_result:supported_points[question_id=afp_context]
  • aasld_hcc_guidance_2023_biomarkers
  • aasld_hcc_guidance_2023_multidisciplinary
  • easl_hcc_guideline_2018_tace
Liver-function assessment is incomplete because required clinical fields are unavailable: bilirubin, albumin, INR, platelets, complete_liver_function_panel.
liver_function_assessment_incomplete · clinical_context
INSUFFICIENT
Derived values
No derived values.
References
  • case_investigation_result:missing_information[name=bilirubin]
  • case_investigation_result:missing_information[name=albumin]
  • case_investigation_result:missing_information[name=INR]
  • case_investigation_result:missing_information[name=platelets]
  • case_investigation_result:missing_information[name=complete_liver_function_panel]
AFP trend is unavailable; only single-value AFP context is present.
afp_trend_unavailable · clinical_context
INSUFFICIENT
Derived values
No derived values.
References
  • case_investigation_result:missing_information[name=AFP_trend]
Source response fields exist, but CLARIS did not complete its own previous/current quantitative imaging comparison.
review_flag_1_source_response_available_without_claris_comparison · review_flags
REVIEW
Derived values
No derived values.
References
  • case_investigation_result:review_flags[0]
Evidence controls
Evidence sufficiencyLIMITED
Supported claims100% (15/15 claims)
Retrieved sources7
Traceable claims15
Missing fields14
Conflicts1
Missing information
Document
  • raw_lab_reportnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • raw_radiology_reportnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
Imaging
  • previous_current_imaging_comparisonPrevious imaging measurements are unavailable.insufficient_data
  • previous_compatible_imaging_measurementsPrevious study compatible mask-derived measurements are unavailable.unavailable
  • quantitative_previous_current_comparisonPrevious imaging measurements are unavailable.insufficient_data
Laboratory
  • ALTnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • ASTnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • bilirubinnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • albuminnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • INRnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • plateletsnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • complete_liver_function_panelnot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
  • AFP_trendAFP trend cannot be calculated from a single source value.insufficient_data
Performance Status
  • ECOG_explicit_sourcenot present in HCC-TACE-Seg metadata/clinical spreadsheetunavailable
Review flags and conflicts
Source response fields exist, but CLARIS did not complete its own previous/current quantitative imaging comparison.review
Review Required
Provenance
Source response fields are available, but CLARIS has not completed a compatible previous/current imaging comparison.review
Unresolved
Provenance Gap
Case timeline
6 events